The bus trip from Calama to Santa Cruz takes a total of 45 hours, including spending the night in Oruro and the crossing of the Chile - Bolivia border through Pisiga-Colchane. The distance between both cities is 1268 km and the highways between them are totally paved. The trip must be made with a scale, since there are no direct trips available. The first part of the trip is from Calama to Oruro. This part of the trip takes around 11 hours. The buses leave at 12:00 from the Bus Terminal of Antofagasta, and arrive in Oruro at 23:00, at the New Bus Terminal. Once in Oruro, you must spend the night since the buses leave in the afternoon. You can rest and visit the city until it is time to take the bus to Santa Cruz, which leaves at 17:00 from the same bus terminal. The duration of this part of the trip is 17 hours, arriving in Santa Cruz at 10:30 the next day, at the Bus Terminal of Santa Cruz.
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