Uyuni is a town that serves as entry gate to the majestic Uyuni Salt Flat; Puno is the peruvian city on the shore of Lake Titicaca. Both are great tourist destinations, and the distance between them is 778 km.
In order to travel from Uyuni to Puno by bus, you must divide the trip in two segments; first from Uyuni to La Paz and then from La Paz to Puno. The buses from Uyuni to La Paz leave every day between 20:30 and 22:00 in the evening, and arrive in La Paz early in the morning at the Bus Terminal. The trip takes around 10 hours. The buses from La Paz to Puno leave from the same terminal, at 8:00, 13:00 and 16:00. The trip takes around 7 hours and the border is crossed through Desaguadero. In total, the more direct trip from Uyuni to Puno takes 17 hours, crossing the bolivian highlands to the peruvian shore of Lake Titicaca.
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